業績

2022.4~2023.3

Yamada H,Deguchi M,Saito S,Takeshita T,Mitsui M,Saito T,Nagamatsu T,Takakuwa K,Nakatsuka M,Yoneda S,Egashira K,Tachibana M,Matsubara K,Honda R,Fukui A,Tanaka K,Sengoku K,Endo T,Yata H.Intravenous immunoglobulin treatment in women with four or more recurrent pregnancy losses:A double-blind,randomised,placebo-controlled trial.eClinicalMedicine2022 ; 50 : 101527

Suzuki Y,Matsubara K,Watanabe K,Tanaka K,Yamamoro T,Nohira T,Mimura K,Suzuki H,Hamada F,Makino S,Koide K,Nishiawa H,Naruse K,Mikami Y,Kawabata I,Yoshimatsu J,Suzuki K,Saito S.A multicenter prospective study of home blood pressure measurement(HBPM)during pregnancy in Japanese women.Hypertension Research 2022 ; 45 : 1563-1574

Maika Oishi , Kanji Tanaka , Kana Ishihara , Kaori Iino , Asami Ito , Yoshihito Yokoyama Current status of long-term follow-up system for women with a history of hypertensive disorders of pregnancy: the HDP-PPAP study (HDP-Postpartum in Aomori prefecture study)The Journal of Maternal-Fetal&Neonatal Medicine 2023 Dec;36(1):2183757.

2021.4～2022.3

Iwasawa T，Takahashi T，Maeda E，Ishiyama K，Takahashi S，Suganuma R，Matsuo K，Tachibana M，Fukuhara R，Shirasawa H，Sato W，Kumazawa Y，Terada Y：Effects of localisation of uterine adenomyosis on outcome of in vitro fertilisation/intracytoplasmic sperm injecion fresh and frozen-thawed embryo transfer cycles:a multicentre retrospective cohort study. Reproductive Biology and Endocrinology 2021 ; 19 : . 84

Hayashi M，Oi R，Otsuki K，Yoneda N，Nagamatsu Y，Kumasaka R，Miyakoshi K，Aoki H，Tanaka K，Kumazawa K，Ohkuchi A，Matsuda Y，Nakai A　　Effects of prophylactic vaginal progesterone administration on mild cervical shortening (TROPICAL study):a multicenter,double-blind,randomized trial. The Journal of Maternal-Fetal&Neonatal Medicine

Shigeto T，Yokoyama Y Treatment strategies for ovarian cancer focusing on prostaglandins European Journal of Gynaecological Oncology 2021 ; 42 : 996−1000 . 5

Azusa Annells，Futagami M，Osawa Y，Oishi M，Washima H，Sugimoto R，Tsushima R，Takenoko K，Kurotaki S，Taguchi T，Maeda J，Kadonosawa Y，Ebina A，Akaishi A，Miura R，Matsumura Y，Yokoyma Y Perioperative heart rate variability analysis to evaluate autonomic activity in gynecologic patients .Hirosaki Medical Journal2022 ; 72 : 51−61

Iino K,Fukuhara R,Yokota M,Yokoyama Y .Fertility awareness and subclinical infertility among women trying to get pregnant at home BMC Women’s Health

2020.4～2021.3

Teshigahara Y，Kakizaki I，Hirao W，Tanaka K，Takahashi R：A Chondroitin Sulfate Chain of Urinary Trypsin Inhibitor Enhances Protease Inhibitory Activity of the Core Protein．The Japanese Society of Applied Glycoscience．67：63-66.2020

Oyama F，Futagami M，Oikiri H，Takabayashi A，Akaishi A，Kodama T，Matsumoto M，Kanamori M，Oishi M，Miura R，Hirakawa H，Yokoyama Y：Quantitative evaluation of chemotherapy-induced peripheral neuropathy by using intraepidermal electrical stimulation．Molecular and Clinical Oncology．13：169-174.2020

Takamatsu K，Ogawa M，Higuchi T，Takada T，Hayashi K，Mizunuma H：Effects of Kamishoyosan,a Traditional Japanese Medicine,on Menopausal Symptoms:A Randomized,Placebo-Controlled,Double-Blind Clinical Trial．Evidence-Based Complementary and Alternative Medicine．https://doi.org/10.1155/2020/9285317

Oyama F，Futagami M，Shigeto T，Miura R，Osawa Y，Oishi M，Oikiri H，Yokoyama M，Takabayashi A，Yokoyama Y：Preventive effect of daikenchuto,a traditional Japanese herbal medicine,on onset of ileus after gynecological surgery for malignant tumors．Asia-Pac J Clin Oncol．16：254-258.2020

Iino K，Tanaka K，Takabayasi A，Akaishi A，Ishihara K，Yokoyama Y：Spontaneous partial uterine laceration in primigravide at 16 weeks of gestation:A case report．International Journal of Surgery Case Reports．73：154-156.2020

Oyama F，Asano Y，Shimoda H，Horie k，Watanabe J，Yokoyama Y：Morphological analysis of peritoneal dissemination of ovarian cancer based on leves of carbonyl reductase 1 expression．Europecan Journal of Gynaecological Oncology：41：352-360.2020

Takabayashi-Ebina A，Yokoyama M，Horie K，Yokoyama Y：Carbonyl reductase 1-overexpressing exosomes inhibit proliferation of ovariancancer cells：Hirosaki Medical Journal．71：120-130．2021

2018.3～2020.3

Kana Ishihara, Kanji Tanaka, Maika oishi, Asami Ito, Yoshihito Yokoyama:Study on long-term prognosis of women with a history of gestational daibetese mellitus in Tugaru district, Aomori prefecture: GDM-PPAP STUDY. Hirosaki Med J.68:157-167.2018

Kazushi Watanabe, Keiichi Matsubara, Osamu Nakamoto, Junko Ushijima, Akihide Ohkuchi, Keiko Koide, Shintaro Makino, Kazuya Mimura, Mamoru Morikawa, Katsuhiko Naruse, Kanji Tanaka, Tomoyoshi Nohira, Hirohito Metoki, Satoru Takeda, Hiroyuki Seki, Kenjiro Takagi, Mineo Yamasaki, Atsuhiro Ichihara, Tadashi Kimura, Shigeru Saito. Outline of the new definition and classification of “Hypertensive Disorders of Pregnancy (HDP)” ; . Hypertens Res Pregnancy.2018;6:33-37.

Seigo Tanaka, Ikuko Kakizaki, Kanji Tanaka, Tomoe Kodama, Asami Ito-Fukuyama, Shinichiro Suto, Ryoki Takahashi, Yoshihito Yokoyama:Development of new therapeutic agents for preterm birth by glycosaminoglycan chain remodeling of urinary trypsin inhibitor. Hypertens Res Pregnancy.2019;7:33-37.

​Takehara K, Yamashita N, Watanabe R, Teramoto N, Tsuda H, Motohashi T HaranoK, Nakanishi T, Tokunaga H, Susumu N, Ueda Y, Yokoyama Y, Saito T. Clinical status and prognostic factors in Japanese patients with uterine leiomyosarcoma. Gynecol Oncol 2020; 157: 115-120.

Watanabe T, Soeda S, Nishiyama H, Kiko Y, Tokunaga H, Shigeta s, Yaegashi N, Yamada H, Ohta T, Nagase S, Shoji T, Kagabu M, Baba T, Shimizu D, Sato N, Terada Y, Futagami M, Yokoyama Y, Fujimori K. Clinical and reproductive outcomes of fertility-sparing surgery in stage I epithelial ovarian cancer. Mol Clin Oncol 2020; 12; 44-50.

Nomura H, Aoki D, Susumu N, Mizuno M, Nakai H, Arai M, Nishio S, Tokunaga H, Nakanishi T, Watanabe Y, Yaegashi N, Yokoyama Y, Takehara K. Analysis of the relapse patterns and risk factors of endometrial cancer following postoperative adjuvant chemotherapy in a phase III randomized clinical trial. Gynecol Oncol 2019; 155: 413-419.

Yoshioka H, Iwaya M, Horie K, Yokoyama Y, Watanabe J. Establishment of nuclear grade evaluation method for endometrial endometrioid carcinoma, and the significance of separately evaluating nuclear atypia of the glandular and solid structure parts. Arch Cytol Histopathol Res 2019; 4: 220-227.

Oikiri H, Asano Y, Matsusaki M, Akashi M, Shimoda H, Yokoyama Y. Inhibitory effect of carbonyl reductase 1 against peritoneal progression of ovarian cancer: evaluation by ex vivo 3D-human peritoneal model. Mol Biol Rep 2019; 46: 4685-4697.

Oikiri H, Futagami M, Watanabe J, Yokoyama Y. Adenocarcinoma of the cervix: its prognosis and difficult pathologic diagnosis. Eur J Gynaecol Oncol 2019; 40: 728-733.

Komiyama S, Nishijima Y, Kondo H, Nomura H, Yamaguchi S, Futagami M, Arai H, Yokoyama Y, Suzuki N, Mikami M, Kubushiro K, Aoki D, Udagawa Y, Nishimura R. Multicenter clinicopathological study of high-grade serous carcinoma presenting as primary peritoneal carcinoma. Int J Gynecol Cancer 2018; 28: 657-665.

Tsuda H, Ito YM, Todo Y, Iba T, Tasaka K, Sutou Y, Hirai K, Dozono K, Dobashi Y, Manabe M, Sakamoto T, Yamamoto R, Ueda K, Akatsuka M, Kiyozuka Y, Nagai N, Imai M, Kobiki K, Fujita H, Itamochi H, Oshita T, Kawarada T, Hatae M, Yokoyama Y. Measurement of endometrial thickness in premenopausal women in office gynecology. Reprod Med Biol 2018; 17: 29-35.

2017.4～2018.3

Yokoyama Y，Shigeto T，Miura R，Kobayashi A，Mizunuma M，Yamauchi A，Futagami M，Mizunuma H.Differences in the sensitivity of ovarian cancer to photodynamic therapy and the mechanisms for those differences.Oncology Letters;13:4933-4938.

​Yamauchi A，Kobayashi A，Oikiri H，Yokoyama Y.Functional role of the Tau protein in epithelial ovarian cancer cells.Reprod Med Biol;16:143−151.

​Oishi M，Tanaka K，Ishihara K，Iino K，Yokoyama Y，Mizunuma H.Results of a questionnaire survey on blood pressure management in hypertensive disorders　of pregnancy in Aomori prefecture,Japan.Hypertension Research in Pregnancy;5:7-12.

​Funamizu A，Fukui A，Fukuhara R，Kobayashi A，Chiba H，Matsumura Y，Ito A，Mizunuma H.A case of bilateral tubal pregnancy.Gynecology and Minimally Invasive Therapy###;6:191-192.

Hamano I，Nakamura R, Fukuhara R，Yokoyama Y　他7名.Onco-testicular sperm extraction (Onco-TESE)from a single testis with metachronous bilateral testicular cancer:a case report.Basic and Clinical Andrology;1:.Dol 10.1186/
s12610-018-0066-2

​Hiroshi T，Yokoyama Y　他22名.Measurement of endometrial thickness in premenopausal women in office gynecology.Reprod Med Biol;17:29-35 .

Ishihara K，Tanaka K，Oishi M，Ito A，Yokoyama Y.STUDY ON LONG-TERM PROGNOSIS OF WOMEN WITH A HISTORY OF GESTATIONAL DIABETES MELLITUS IN TSUGARU DISTRICT,AOMORI PREFECTURE GDM POSTPARTUM IN AOMORI PREFECTURE STUDY(GDM-PPAP STUDY).THE HIROSAKI MEDICAL JOURNAL;68:157-167.

​Komiyama S，Futagami M，Yokoyama Y　他11名.Multicenter Clinicopathological Study of High-Grade Serous Carcinoma Presenting as Primary Peritoneal Carcinoma..Int J Gynecol Cancer;28:657ｰ665.4DOl 10.1097/IGC.0000000000001167

​Shoji T，Futagami M，Yokoyama Y　他16名.A phase Ⅱ study of irinotecan and pegylated liposomal doxorubicin in platinum-resistant recurrent ovarian cancer(Tohoku Gynecologic Cancer Unit 104 study).Cancer Chemother Pharmacol;80:355-361.

​Suzuki Y，Tanaka K　他18名.Home blood pressure measurement(HBPM)for the early detection of hypertensive disorders of pregnancy(HDP)in Japanese women:a multicenter prospective study .hypertension Research in Pregnancy;5:36-38 .2

Itamachi H，Yokoyama Y　他15名.Whole-genome sequencing revealed novel prognostic biomarkers and promising targets for therapy of ovarian clear cell carcinoma.British Journal of Cancer:717-724.dol:10.1038/bjc.2017.228

​Fukui A，Funamizu A，Fukuhara R，Shibahara H.Expression of natural cytotoxicity receptors and cytokine production on endometrial natural killer cells in women with recurrent pregnancy loss or implantation failure,and the expression of natural cytotoxicity receptors on peripheal blood natural killer cells in pregnant women with a history of recurrent pregnancy loss.Obstetrics and Gynaecology　Research;43:1678-1686.11dol:10.1111/jog.13448